Aldactone™

[Spironolactone]

Aldactone

Description / Properties

Aldactone (Spironolactone) is a potassium-sparing diuretic. Spironolactone is a synthetic 17-spirolactone steroid that is competititive antagonist of aldosterone. Spironolactone is used as an antihypertensive agent. It frequently is used to treat ascites associated with cirrhosis and also has been used as a diagnostic aid for primary hyperaldosteronism. Spironolactone is a poor agent for treating hypertension or generalized edema, although its effects can be additive with thiazide diuretics. It was approved by the FDA in 1960.

Indications

Edema.

Drug Interactions

Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, NSAIDs. Hypokalemia with corticosteroids, ACTH. Antagonized by NSAIDs. Potentiates ganglionic blockers, alcohol, barbiturates, narcotics, skeletal muscle relaxants. Digitalis toxicity.

Side Effects

Hyperkalemia, hyponatremia, gynecomastia, GI disturbances, drowsiness, headache, rash, confusion, drug fever, ataxia, impotence, hirsutism, voice deepening, menstrual changes, gastric ulcers, agranulocytosis.

Warning and Precautions

Hepatic cirrhosis. Hyponatremia. Surgery. Monitor electrolytes. Pregnancy. Nursing mothers: not recommended.

Dosage

Initially 25–200mg daily. Usual starting dosage: 100mg/day in single or divided doses. Maintain for 5 days, then retitrate.

Presentations Available

Aldactone is available in 25 & 100mg tablets.

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