Gravinate™

[Dimenhydrinate]

Gravinate

Indications

Motion sickness, vertigo, nausea or vomiting associated with: electroshock therapy, anesthesia and surgery, labyrinthine disturbance, radiation sickness and post fenestration syndrome.

Contraindication

Clinical studies in pregnant women have not indicated that Gravinate increase the risk of fetal abnormalities, it like any drug should be used during pregnancy only if benefits out weight the risks.

Drug Interactions

Caution should be used when Gravinate is given in conjunction with certain antibiotics, which may cause ototoxicity, since Gravinate is capable of masking ototoxicity symptoms and an irreversible state may be reached.

Side Effects

Drowsiness may be experienced in some patients, especially those on high dosage, although this effect frequently is not undesirable in some conditions for which the drug is used.

Warning and Precautions

Patient should be cautioned against operating automobiles or dangerous machinery while talking Gravinate because of possible drug associated drowsiness.

Dosage

Oral-Children; A liquid form containing 12.5mg of Gravinate per 4ml is available. The liquid dosage form is recommended for Children. For children 5mg/kg daily in 2 or 3 divided doses is recommended. Children: 2-6 years: one to two teaspoonful (4ml). 2 to 3 times daily. 6-12 years: Two to four teaspoonful (4ml) 2 to 3 times daily. Children under 2 years: only on advice of a physician. Tablets: Ages 6 to 5 years. 12.5mg to 25mg ( to tablets) two or three times daily. Ages 6 to 12 years. 25mg to 50mg ( to one tablet) two or three times daily. Age 12 or older: 50mg (one tablet) two or three times daily. Adults: The Adult therapeutic and prophylactic dose is 50 to 100mg (one two tablets) three times daily. For prevention of motion sickness, the first dose should be given 30 minutes before departure. Parenteral: For intramuscular administration each milliliter of solution (50mg Gravinate) or poison is injected undiluted as required. Adults 50 to 100mg (1 to 2ml) intramuscularly as required by the condition being treated. The most common dosage is 50mg every four hours. Children: The intramuscular dosage of Gravinate should be 1.25mg/kg four times daily, up to maximum of 300mg/day. For intravenous administration each milliliter of solution or portion should be diluted in 10mgl of isotonic sodium chloride and injected over a period of two minutes. Gravinate injectable may be given in I.V. infusion. Adults; 50 to 100mg (1 to 2ml) intravenously as required by the conditions being treated. The most common dosage is 50mg every four hours. Children: The intravenous dosage is 50mg every four hour. Children: The intravenous dosage of Gravinate should the 1.25mg/kg four times daily, up to maximum of 300mg/day.

Presentations Available

Tablets: Boxes of 100 tablets (10 * 10s blister strips).

Liquid: Bottle of 60ml.

Ampoules: Boxes of 25 ampoules

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