Serenace™
[Haloperidol]
Description / Properties
Haloperidol is a tranquilizer which also has antiemetic, hypotensive and hypothermic actions. Administered orally or intramuscularly. Haloperidol is a neuroleptic/antipsychotic agent. Haloperidol is used to treat schizophrenia (mental disorder), to control of the vocal utterances and tics (an involutary, compulsive, repetative, and stereotype movement of face and shoulders) of tourette's syndrome and to control agitated and disrupted behavior.
Drug Interactions
Haloperidol is known to interact with other drugs like Adrenaline, Amiodarone (HCl), Buspirone (HCl), Carbamazepine, Clomipramine (HCl), Clonidine (HCl), Clozapine, Dexamphetamine (Sulphate), Dextromethorphan (HBr), Droperidol, Guanethidine, Haloperidol, Imipramine (HCl), Indomethacin, Indomethacin, Levodopa, Lithium, Methylamphetamine, Methyldopa, Metoclopramide (HCl), Paroxetine (HCl), Prochlorperazine, Protriptyline (HCl), Rifampicin, Ritonavir.These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
The severe or irreversible adverse effects of Haloperidol, which give rise to further complications include Tardive dyskinesia, Parkinsonism, Neurological complications, Akathisia, Oculogyric dystonia, Torticollis, Grimacing.Haloperidol produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome, Neuroleptic sudden death syndrome. which are responsible for the discontinuation of Haloperidol therapy.The signs and symptoms that are produced after the acute overdosage of Haloperidol include Hypotension, Unconsciousness, Respiratory depression, Extrapyramidal effects.The symptomatic adverse reactions produced by Haloperidol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Constipation, Dry mouth, Blurred vision, Urinary retensionX, Nasal stiffiness, Orthostatic hypotension, Urinary frequency, Cardiovascular effects.
Warning and Precautions
Under construction
Dosage
The dosage range can vary between 1 mg and over 200 mg per day depending on the condition and the individuals response to treatment. Dosage should be titrated to clinical efficacy, and then reduced to the lowest effective level. Safety of prolonged administration of high dosages has not been demonstrated by controlled clinical trials. Children and debilitate or geriatric patients may be more sensitive to haloperidol and require adjustment of the starting dose.
ORAL
ADULTS: Normally, treatment may be started at 10-15 mg daily and increased until satisfactory control is achieved. When maximum improvement is reached, this should be gradually reduced to the lowest effective maintenance dose which for many patients will be I to 10 mg per day. For treatment of anxiety and tension states, the usual dosage Is 0.5 to 1.0 mg daily.
CHILDREN: Serenace is not intended for children under 3 years old.
Maintenance Dosage: 0.05 mg per kg body weight per day. This is equivalent to one drop morning and evening per 4 kg body weight. Where control is not urgent, treatment may be initiated at half the above level upto the maintenance dosage.
PARENTERAL
Adults: For rapid emergency control, 10mg will normally be adequate. Up to 30mg may be given by intramuscular injection. Further doses may be repeated every six hours until control is achieved. At that time, oral dosage may be substituted in diminishing doses. The intravenous route may be used if required.
Children: Serenace is not intended for children under 3 years old.
Maintenance Dosage: 0.05 mg per kg body weight per day. Where control is not urgent, treatment may be initiated at half the above level up to the maintenance dosage. In adults, therapy may be started at two or three times the maintenance dosage, and may be combined with anti-Parkinsonian drugs. The use is recommended as a short-term treatment and should be reserved for those patients that fail to respond to psychotherapy or medications other than neuroleptics.
Presentations Available
Serenace Tablets: 0.25mg / 1.5mg / 5mg / 10mg
Serenace Drops: 15m1 Bottles
Serenace Ampoules
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