Vaptor™
[Rosuvastatin]
Description / Properties
Vaptor™ (Rosuvastatin) is a selective and competitive inhibitor of HMG-Co A reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol. The primary site of action of Rosuvastatin is the liver, the target organ for cholesterol lowering.
Indications
Vaptor™ (Rosuvastatin) is indicated: As an adjunct to diet to reduce elevated Total-C, LDL-C, non HDL-C, ApoB, and triglycerides levels and to increase HDL-C in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Hyperlipoproteinaemias/ Fredrickson Types Ila and Ilb). As an adjunct to diet for the treatment of patients with elevated serum TG levels (Hypertriglyceridaemia/Fredrickson Type IV). To reduce Total-C, LDL-C and ApoB in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other nonpharmacological or lipid lowering treatments (e.g. LDL apheresis) or if such treatments are unavailable or inadequate.
Side Effects
Rosuvastatin is generally well tolerated. Adverse reactions have usually been mild and transient.
Warning and Precautions
Before instituting therapy with Rosuvastatin, an attempt should be made to control hypercholesterolemia with appropriate diet, exercise, and weight reduction in obese patients, and to treat other underlying medical problems, When initiating statin therapy or switching from another statin therapy, the appropriate Rosuvastatin starting dose should first be utilized and only then titrated according to the patient's individualized goal of therapy. HMG-CoA reductase inhibitors, like some other lipid lowering therapies, have been associated with biochemical abnormalities of liver function. It is recommended that liver function tests be performed before and at 12 weeks following both the initiation of therapy and any elevation of dose and periodically thereafter. Paediatric Safety and efficacy of Rosuvastatin have not been established in children.
Dosage
The patient should be placed on a standard cholesterol lowering diet before receiving Vaptor™ (Rosuvastatin) and should continue on this diet during treatment with Vaptor™ (Rosuvastatin). Vaptor™ (Rosuvastatin) can be administered as a single dose at any time of day, with or without food.
Presentations Available
Vaptor™ 5mg: light brown colour film-coated tablets in alu-alu blister pack of 10
Vaptor™ 10mg: peach colour film-coated tablets in alu-alu blister pack of 10
Vaptor™ 20mg: light brown colour film-coated tablets in alu-alu blister pack of 10
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